Victorian explorer Sir Richard Burton, who drank from the Fountain of Youth and now works as a taxidermist at the Toronto Natural History Museum, is doing research on ‘Patient Zero’, a gay flight attendant who allegedly brought HIV to North America. Meanwhile, the ghost of Patient Zero materializes and in a comedy of errors, encounters Burton. They fall in love and attempt to figure out what to do about the scientist's past attempts to defame Patient Zero as a "sexual serial killer".